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29 Dec 2016 - MedXpress - Omega-3 supplements can prevent childhood asthma

FAB RESEARCH COMMENT:

Supplementing pregnant mothers with high-dose long-chain omega-3 fatty acids (EPA/DHA) reduced asthma rates in their children by over 30% in their first 3 years, according to this new clinical trial.

Reductions in childhood asthma from maternal omega-3 supplementation in pregnancy were even greater for mothers with the lowest blood levels of long-chain omega-3. In their children asthma rates were reduced by more than half. For details of this research, see:

Earlier this year, US researchers reported that supplementing all pregnant mothers with DHA could lead to huge savings in healthcare costs, based on their results from randomised controlled trials: 

However, as with similar findings last year from Australia, their calculations only included immediate hospital costs - with most of the cost savings attributable to reduced prematurity rates following omega-3 supplementation of mothers during pregnancy. They did not include any estimates of future cost savings in relation to education, healthcare or social cost burdens.

These latest data suggest that if childhood asthma prevention alone were factored in, the overall cost savings would be even more significant.

Taking certain omega-3 fatty acid supplements during pregnancy can reduce the risk of childhood asthma by almost one third, according to a new study from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) and the University of Waterloo.

The study, published in the New England Journal of Medicine, found that women who were prescribed 2.4 grams of long-chain omega-3 supplements during the third trimester of pregnancy reduced their children's risk of asthma by 31 per cent. Long-chain omega-3 fatty acids, which include eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are found in cold water fish, and key to regulating human immune response.

"We've long suspected there was a link between the anti-inflammatory properties of long-chain omega-3 fats, the low intakes of omega-3 in Western diets and the rising rates of childhood asthma," said Professor Hans Bisgaard of COPSAC at the Copenhagen University Hospital. "This study proves that they are definitively and significantly related."

The study used rapid analytical techniques developed and performed at the University of Waterloo to measure levels of EPA and DHA in pregnant women's blood. The University of Waterloo is one of a few laboratories in the world equipped to run such tests.

"Measuring the levels of omega-3 fatty acids in blood provides an accurate and precise assessment of nutrient status," said Professor Ken Stark, Canada Research Chair in Nutritional Lipidomics and professor in the Faculty of Applied Health Sciences at Waterloo, who led the testing. "Our labs are uniquely equipped to measure fatty acids quickly, extremely precisely, and in a cost-efficient manner."

The testing also revealed that women with low blood levels of EPA and DHA at the beginning of the study benefitted the most from the supplements. For these women, it reduced their children's relative risk of developing asthma by 54 per cent.

"The proportion of women with low EPA and DHA in their blood is even higher in Canada and the United States as compared with Denmark. So we would expect an even greater reduction in risk among North American populations," said Professor Stark. "Identifying these women and providing them with supplements should be considered a front-line defense to reduce and prevent childhood asthma."

Researchers analyzed blood samples of 695 Danish women at 24 weeks' gestation and one week after delivery. They then monitored the health status of each participating child for five years, which is the age asthma symptoms can be clinically established.

"Asthma and wheezing disorders have more than doubled in Western countries in recent decades," said Professor Bisgaard. "We now have a preventative measure to help bring those numbers down."

Currently, one out of five young children suffer from asthma or a related disorder before school age.

Web URL: Read the full article on MedicalXpress here

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