A randomized trial (VITACOG) in people with mild cognitive impairment (MCI) found that B vitamin treatment to lower homocysteine slowed the rate of cognitive and clinical decline. We have used data from this trial to see whether baseline omega-3fattyacidstatus interacts with the effects of Bvitamin treatment.
266 participants with MCI aged ≥70 years were randomized to Bvitamins (folic acid, vitamins B6 and B12) or placebo for 2 years. Baseline cognitive test performance, clinical dementia rating (CDR) scale, and plasma concentrations of total homocysteine, total docosahexaenoic and eicosapentaenoic acids (omega-3fatty acids) were measured.
Final scores for verbal delayed recall, global cognition, and CDR sum-of-boxes were better in the B vitamin-treated group according to increasing baseline concentrations of omega-3fatty acids, whereas scores in the placebo group were similar across these concentrations.
Among those with good omega-3status, 33% of those on B vitamin treatment had global CDR scores >0 compared with 59% among those on placebo. For all three outcome measures, higher concentrations of docosahexaenoic acid alone significantly enhanced the cognitive effects of Bvitamins, while eicosapentaenoic acid appeared less effective.
When omega-3fattyacidconcentrations are low, B vitamin treatment has no effect on cognitivedecline in MCI, but when omega-3 levels are in the upper normal range, B vitamins interact to slow cognitivedecline. A clinical trial of Bvitamins combined with omega-3fatty acids is needed to see whether it is possible to slow the conversion from MCI to AD.
FAB RESEARCH COMMENT:
For a summary of this research, see the associated news article here:
FAB Research 163 Woodford Road Woodford Cheshire SK7 1QD
Medical opinion and guidance should always be sought for any symptoms that might possibly reflect a known or suspected disease, disorder or medical condition. Information provided on this website (or by FAB Research via any other means) does not in any way constitute advice on the treatment of any medical condition formally diagnosed or otherwise.