Butwicka A, Lichtenstein P, Frisén L, Almqvist C, Larsson H, Ludvigsson JF (2017) Pediatr. 2017 Mar 7. pii: S0022-3476(17)30153-1. doi: 10.1016/j.jpeds.2017.01.043. [Epub ahead of print]
To determine the risk of future childhood psychiatric disorders in celiac disease, assess the association between previous psychiatric disorders and celiac disease in children, and investigate the risk of childhood psychiatric disorders in siblings of celiac disease probands.
This was a nationwide registry-based matched cohort study in Sweden with 10 903 children (aged
Compared with the general population, children with celiac disease had a 1.4-fold greater risk of future psychiatric disorders. Childhood celiac disease was identified as a risk factor for mood disorders, anxiety disorders, eating disorders, behavioral disorders, ADHD, ASD, and intellectual disability. In addition, a previous diagnosis of a mood, eating, or behavioral disorder was more common before the diagnosis of celiac disease. In contrast, siblings of celiac disease probands were at no increased risk of any of the investigated psychiatric disorders.
Children with celiac disease are at increased risk for most psychiatric disorders, apparently owing to the biological and/or psychological effects of celiac disease.