Food and Behaviour Research

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Coffee intake and the incident risk of cognitive disorders: A dose-response meta-analysis of nine prospective cohort studies

Wu L, Sun D, He Y (2017) Clin Nutr.  2017 Jun;36(3): 730-736. doi: 10.1016/j.clnu.2016.05.015. Epub 2016 May 30. 

Web URL: Read this and related abstracts on PubMed here



Previous epidemiological studies have provided inconsistent conclusions on the impact of coffee consumption in the developing of cognitive disorders. However, no previous meta-analysis has pooled the evidence from the prospective cohort studies to assess the influence of coffee drinking and its potential dose-response patterns on the risk of developing cognitive disorders specifically.


Two databases (PubMed and Embase) were searched for evidence of cohort studies from inception to February 2016. We used a generic inverse-variance method with a random-effects model to pool the fully adjusted relative risks (RRs) and the corresponding 95% confidence intervals (CIs). In the dose-response analyses, a generalized least-squares trend estimation model was applied to computing the study-specific slopes.


Nine prospective cohort studies involving 34,282 participants were included in our study. The duration of follow-up years ranged from 1.3 to 28. Compared with2 = 25%). Non-significant differences were presented for the association between coffee consumption (>3 vs.


A "J-shaped" association was presented between coffee intake and incident cognitive disorders, with the lowest risk of incident cognitive disorders at a daily consumption level of 1-2 cups of coffee.


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