Food and Behaviour Research

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Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice

Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng C-P, Huang Y, Haldar S, Verdin E (2017) Cell Metab.  26; 3  547–557 dx.doi.org/10.1016/j.cmet.2017.08.004 

Web URL: Read the abstract and full study on cell.com here

Abstract:

Ketogenic diets recapitulate certain metabolic aspects of dietary restriction such as reliance on fatty acid metabolism and production of ketone bodies.

We investigated whether an isoprotein ketogenic diet (KD) might, like dietary restriction, affect longevity and healthspan in C57BL/6 male mice. We find that Cyclic KD, KD alternated weekly with the Control diet to prevent obesity, reduces midlife mortality but does not affect maximum lifespan. A non-ketogenic high-fat diet (HF) fed similarly may have an intermediate effect on mortality. Cyclic KD improves memory performance in old age, while modestly improving composite healthspan measures. Gene expression analysis identifies downregulation of insulin, protein synthesis, and fatty acid synthesis pathways as mechanisms common to KD and HF. However, upregulation of PPARα target genes is unique to KD, consistent across tissues, and preserved in old age.

In all, we show that a non-obesogenic ketogenic diet improves survival, memory, and healthspan in aging mice.