Food and Behaviour Research

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Impact of Three Doses of Vitamin D3 on Serum 25(OH)D Deficiency and Insufficiency in At-Risk Schoolchildren

Sacheck JM, Van Rompay MI, Chomitz VR, Economos CD, Eliasziw M, Goodman E, Gordon CM, Holick MF (2017) J Clin Endocrinol Metab.  2017 Sep.  doi: 10.1210/jc.2017-01179. [Epub ahead of print] 

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We investigated the daily dose of vitamin D needed to achieve serum 25-hydroxyvitamin D [25(OH)D] sufficiency among schoolchildren at-risk for deficiency.


The Daily D Health Study was a randomized double-blind vitamin D supplementation trial among racially/ethnically diverse schoolchildren (n=685) in the northeastern U.S. Children were supplemented with vitamin D3 at 600, 1000, or 2000 IU/day for six months. Measurements included serum 25(OH)D at baseline (Oct-Dec), 3 months (Jan-March), 6 months (April-June), and 12 months (6 months post-supplementation).


At baseline, mean ± SD serum 25(OH)D was 22.0 ± 6.8 ng/mL; with 5.5% severely vitamin D deficient (


Children who are at risk for vitamin D deficiency benefit from daily sustained supplementation of 2000 IU/day compared to lower doses closer to the current RDA for vitamin D intake. This benefit occurred over the winter months when serum 25(OH)D levels tend to fall.


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