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Childhood diet has lifelong impact

University of California - Riverside

boy eating melon

"You are not only what you eat, but what you ate as a child"


Abundant evidence already shows that

1) modern western-type diets, high in both sugar and refined carbohydrates and processed fats, have many damaging effects on both physical and mental health

2) poor nutrition in early life, particularly during prenatal develpment and early childhood, is associated with lifelong negative outcomes

3) the 'gut microbiome' - the ecosystem involving trillions of bacteria and other microbes that populate the human gut - plays a critical role in health and disease - and diet plays a major role in shaping this.

What this new study adds is evidence that:

  • consuming a western-type diet during childhood only (from weaning until adolescence) significantly reduces gut microbial diversity and balance; and what's more
  • these effects on the gut microbiome persist well into adulthood, even after a healthier diet is restored.
  • exercise also affects gut microbial balance (as do genetic factors) - but to a lesser extent than diet
Controlled studies like this one can only ever be carried out with animals - and it's never possible to be certain that similar effects would apply to humans.

However, these findings are consistent with plenty of other evidence that children eating modern, western-type diets rich in ultra-processed foods have higher risks for both physical and mental health problems not only in childhood, but throughout later life.

For the related research article please see:

For further information on this topic please see:

03/02/2021 - ScienceDaily

Eating too much fat and sugar as a child can alter your microbiome for life, even if you later learn to eat healthier, a new study in mice suggests.

The study by UC Riverside researchers is one of the first to show a significant decrease in the total number and diversity of gut bacteria in mature mice fed an unhealthy diet as juveniles.

"We studied mice, but the effect we observed is equivalent to kids having a Western diet, high in fat and sugar and their gut microbiome still being affected up to six years after puberty," explained UCR evolutionary physiologist Theodore Garland.

A paper describing the study has recently been published in the Journal of Experimental Biology.

The microbiome refers to all the bacteria as well as fungi, parasites, and viruses that live on and inside a human or animal. Most of these microorganisms are found in the intestines, and most of them are helpful, stimulating the immune system, breaking down food and helping synthesize key vitamins.

In a healthy body, there is a balance of pathogenic and beneficial organisms. However, if the balance is disturbed, either through the use of antibiotics, illness, or unhealthy diet, the body could become susceptible to disease.

In this study, Garland's team looked for impacts on the microbiome after dividing their mice into four groups: half fed the standard, 'healthy' diet, half fed the less healthy 'Western' diet, half with access to a running wheel for exercise, and half without.

After three weeks spent on these diets, all mice were returned to a standard diet and no exercise, which is normally how mice are kept in a laboratory. At the 14-week mark, the team examined the diversity and abundance of bacteria in the animals.

They found that the quantity of bacteria such as Muribaculum intestinale was significantly reduced in the Western diet group. This type of bacteria is involved in carbohydrate metabolism.

Analysis also showed that the gut bacteria are sensitive to the amount of exercise the mice got. Muribaculum bacteria increased in mice fed a standard diet who had access to a running wheel and decreased in mice on a high-fat diet whether they had exercise or not.

Researchers believe this species of bacteria, and the family of bacteria that it belongs to, might influence the amount of energy available to its host. Research continues into other functions that this type of bacteria may have.

One other effect of note was the increase in a highly similar bacteria species that were enriched after five weeks of treadmill training in a study by other researchers, suggesting that exercise alone may increase its presence.

Overall, the UCR researchers found that early-life Western diet had more long-lasting effects on the microbiome than did early-life exercise.
Garland's team would like to repeat this experiment and take samples at additional points in time, to better understand when the changes in mouse microbiomes first appear, and whether they extend into even later phases of life.

Regardless of when the effects first appear, however, the researchers say it's significant that they were observed so long after changing the diet, and then changing it back.

The takeaway, Garland said, is essentially, "You are not only what you eat, but what you ate as a child!"