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Consumption of added sugar doubles fat production

University of Zurich

sugary drink

Eighty grams of sugar daily, which is equivalent to about 0,8 liters of a normal soft drink, boosts fat production in the liver.


In healthy young men, fat production in the liver was doubled after 7 weeks of consuming a daily drink sweetened with either fructose or ordinary sugar (which is an equal mix of fructose and glucose) - but no such effects were seen when the drink was sweetened with pure glucose.

Importantly, these effects of fructose were independent of total energy intake, because total calories consumed did not increase throughout the study. 

This was a randomised controlled trial, a study design which means that the results provide good evidence for a causal effect of fructose in boosting liver fat production. 

They support existing findings from animal studies, and help to explain the strong links between the consumption of high-sugar foods and drinks and the development of non-alcoholic fatty liver disease, obesity, Type 2 diabetes and other metabolic conditions.

Fructose alone, or fructose combined with glucose (as found in ordinary sugar) increased fat production - but glucose alone did not. This is entirely in keeping with what animal studies have shown.

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16/03/2021 - Medical Xpress

Too much sugar is unhealthy—that we know, but it's not just down to the many calories.

Even moderate amounts of added fructose and sucrose double the body's own fat production in the liver, researchers from the University of Zurich and the University Hospital Zurich have shown. In the long term, this contributes to the development of diabetes or a fatty liver.

Sugar is added to many common foodstuffs, and people in Switzerland consume more than 100 grams of it every day. The high calorie content of sugar causes excessive weight and obesity, and the associated diseases. But does too much sugar have any other harmful effects if consumed regularly? And if so, which sugars in particular?

Even moderate amounts of sugar increase fat synthesis

Researchers at the University of Zurich (UZH) and the University Hospital Zurich (USZ) have been investigating these questions. Compared to previous studies, which mainly examined the consumption of very high amounts of sugar, their results show that even moderate amounts lead to a change in the metabolism of test participants.

"Eighty grams of sugar daily, which is equivalent to about 0,8 liters of a normal soft drink, boosts fat production in the
liver. And the overactive fat production continues for a longer period of time, even if no more sugar is consumed," says study leader Philipp Gerber of the Department of Endocrinology, Diabetology and Clinical Nutrition.

Ninety-four healthy young men took part in the study. Every day for a period of seven weeks, they consumed a drink sweetened with different types of sugar, while the control group did not. The drinks contained either fructose, glucose or sucrose (table sugar which is a combination of fructose and glucose). The researchers then used tracers (labeled substances that can be traced as they move through the body) to analyze the effect of the sugary drinks on the lipid metabolism.

Fructose and sucrose double fat production beyond food intake

Overall, the participants did not consume more calories than before the study, as the sugary drink increased satiety and they therefore reduced their calorie intake from other sources. Nevertheless, the researchers observed that fructose has a negative effect.  

"The body's own fat production in the liver was twice as high in the fructose group as in the glucose group or the control group—and this was still the case more than twelve hours after the last meal or sugar consumption," says Gerber.

Particularly surprising was that the sugar we most commonly consume, sucrose (containing equal amounts of glucose and fructose) boosted fat synthesis slightly more than the same amount of fructose. Until now, it was thought that fructose was most likely to cause such changes.

Development of fatty liver or diabetes more likely

Increased fat production in the liver is a significant first step in the development of common diseases such as fatty liver and type-2 diabetes. From a health perspective, the World Health Organization recommends limiting daily sugar consumption to around 50 grams or, even better, 25 grams.

"But we are far off that mark in Switzerland," says Philipp Gerber. "Our results are a critical step in researching the
harmful effects of added sugars and will be very significant for future dietary recommendations."