Food and Behaviour Research

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Omega-3 and Depression - Research - Clinical Trials

Lu Y et al 2023 - Clinical impacts of n-3 fatty acids supplementation on depression symptoms: an umbrella review of meta-analyses
Mischoulon D et al 2022 - Omega-3 Fatty Acids for Major Depressive Disorder With High Inflammation: A Randomized Dose-Finding Clinical Trial
Bozzatello P et al 2021 - Mental Health in Childhood and Adolescence: The Role of Polyunsaturated Fatty Acids
Saunders E et al 2021 - Adjunctive dietary intervention for bipolar disorder: a randomized, controlled, parallel-group, modified double-blinded trial of a high n-3 plus low n-6 diet
Borsini A et al 2021 - Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression and for human hippocampal neurogenesis
Karaszewska D et al 2021 - Marine Omega-3 Fatty Acid Supplementation for Borderline Personality Disorder
Madison A et al 2021 - Omega-3 supplementation and stress reactivity of cellular aging biomarkers: an ancillary substudy of a randomized, controlled trial in midlife adults
Bai et al 2019 - Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder
Firth et al 2019 - The efficacy and safety of nutrient supplements in the treatment of mental disorders
Guu et al 2019 - International Society for Nutritional Psychiatry Research Practice Guidelines for Omega-3 Fatty Acids in the Treatment of Major Depressive Disorder
Chang et al 2019 - Omega-3 Polyunsaturated Fatty Acids (n-3 PUFAs) in Cardiovascular Diseases Comorbid Major Depressive Disorder (MDD)- Results from a Randomized Controlled Trial
Bot et al 2019 - Effect of Multinutrient Supplementation and Food-Related Behavioral Activation Therapy on Prevention of Major Depressive Disorder Among Overweight or Obese Adults With Subsyndromal Depressive Symptoms
Nishi et al 2019 - Plasma estradiol levels and antidepressant effects of omega-3 fatty acids in pregnant women
Portnoy et al 2018 - Reductions of intimate partner violence resulting from supplementing children with omega-3 fatty acids
Marx et al 2017 - Nutritional psychiatry: the present state of the evidence.
Sarris 2017 - Clinical use of nutraceuticals in the adjunctive treatment of depression in mood disorders.
Messamore et al 2017 - Polyunsaturated fatty acids and recurrent mood disorders: Phenomenology, mechanisms, and clinical application.
Sarris et al 2016 - Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses
Hallahan et al 2016 - Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression
Mocking et al 2016 - Meta-analysis and meta-regression of omega-3 PUFA supplementation for major depression.
Su 2015 - Nutrition, psychoneuroimmunology and depression: the therapeutic implications of omega-3 fatty acids in interferon-α-induced depression.
Appleton et al 2015 - Omega-3 fatty acids for depression in adults
Amminger et al 2015 - Longer-term outcome in the prevention of psychotic disorders by the Vienna omega-3 study.
Raine et al, 2015 - Reduction in behavior problems with omega-3 supplementation in children aged 8-16 years
Deacon et al 2017 - Omega 3 Fatty Acids and the Treatment of Depression.
Rapaport et al., 2015 - Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study.
Su et al, 2014 - Omega-3 Fatty acids in the prevention of interferon-alpha-induced depression
Aliev et al 2013 - Nutritional and Nonnutritional Factors in the Preservation of Cognitive Performance in Dementia/Depression and Alzheimer's Disease
Andreeva et al 2012 - Supplementation with B vitamins or n-3 fatty acids and depressive symptoms in cardiovascular disease survivors.
Mozaffari-Khosravi et al 2012 - EPA versus DHA in mild-to-moderate depression: A randomized, double-blind, placebo-controlled trial.
Kiecolt-Glaser et al 2012 - Omega-3 Supplementation Lowers Inflammation in Healthy Middle-Aged and Older Adults: A Randomized Controlled Trial
Sinn et al 2012 - Effects of n-3 fatty acids, EPA v. DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment
Martins et al 2012 - Eicosapentaenoic acid appears to be the key omega-3 fatty acid component associated with efficacy in major depressive disorder: a critique of Bloch and Hannestad and updated meta-analysis
Mischoulon 2011 - The Impact of Omega-3 Fatty Acids on Depressive Disorders and Suicidality
Bloch & Hannestad 2011 - Omega-3 fatty acids for the treatment of depression: systematic review and meta-analysis
Sublette et al 2011 - Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression
Politi et al 2011 - Randomized Placebo-Controlled Trials of Omega-3 Polyunsaturated Fatty Acids in Psychiatric Disorders: a Review of Current Literature
Lesperance et al 2011 - The efficacy of omega-3 supplementation for major depression: a randomized controlled trial
Tajalizadekhoob et al 2011 - Low-dose omega 3 for mild to moderate depression in the elderly: a randomised controlled trial
Rondanelli et al 2011 - Long chain omega 3 PUFA supplementation in the treatment of elderly depression
Jans et al 2010 - The efficacy of n-3 fatty acids DHA and EPA (fish oil) for perinatal depression
Makrides et al 2010 - Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial.
Borja-Hart & Marino 2010 - Role of omega-3 Fatty acids for prevention or treatment of perinatal depression
Martins 2009 - EPA but not DHA appears to be responsible for the efficacy of omega-3 LC-PUFA supplementation in depression: evidence from a meta-analysis of randomized controlled trials
Leung & Kaplan 2009 - Perinatal depression: prevalence, risks, and the nutrition link--a review of the literature.
van de Rest et al 2008 - Effect of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial.
Su et al 2008 - Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial
Jazayeri et al 2008 - Therapeutic effects of omega-3 EPA and fluoxetine, separately and in combination, in major depression
Richardson 2008 - Omega-3 Fatty acids and Mood: The Devil is in the Detail
Rogers et al 2007 - No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial
Lin & Su 2007 - A meta-analytic review of double-blind, placebo-controlled trials of antidepressant efficacy of omega-3 fatty acids
Hallahan et al. 2007 - Omega-3 supplementation for self-harm: randomised controlled trial
Appleton et al. 2006 - Omega-3 for mood disorders
Freeman et al. 2006 - Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry
Nemets et al 2006 - Omega-3 treatment of childhood depression: a controlled, double-blind pilot study.
Parker et al 2006 - Omega-3 fatty acids and mood disorders.
Freeman et al 2006 - Randomized dose-ranging pilot trial of omega-3 for postpartum depression.
Fontani et al 2005 - Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects
Fontani et al, 2005 - Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with Omega-3 polyunsaturated fatty acids.
Silvers et al 2005 - Randomised controlled trial of fish oil in the treatment of depression
Bradbury et al 2004 - An adaptogenic role for omega-3 fatty acids in stress; a pilot RCT
Peet 2003 - EPA in the treatment of schizophrenia and depression: rationale and preliminary double-blind clinical trial results.
Llorente et al 2003 - Effect of maternal DHA supplementation on postpartum depression and information processing.
Zanarini et al 2003 - Omega-3 fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study
Nemets et al 2002 - Add-on treatment with omega-3 fatty acids in recurrent depression
Peet & Horrobin 2002 - A dose-ranging study of EPA treatment in depression
Calabrese et al 1999 - Fish oils and bipolar disorder: a promising but untested treatment.
Stoll & Marangell 1999 - Reply to commentary on fish oils in bipolar disorder