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Clinical impacts of n-3 fatty acids supplementation on depression symptoms: an umbrella review of meta-analyses

Lu Y, Qiao D, Mi G (2023) The British Journal of Nutrition Oct 27:1-10 doi: 10.1017/S000711452300226X 

Web URL: Read this article on PubMed

Abstract:

Several meta-analyses investigating the efficacy of n-3 PUFA in alleviating depression symptoms have reported conflicting findings. In the present study, we aimed to perform an umbrella meta-analysis to provide a definite conclusion.

A comprehensive systematic search of PubMed, Scopus, Embase, Web of Science and Cochrane Central Library was performed up to June 2021. Meta-analysis studies evaluating the effects of 
n-3 PUFA on depression symptoms were included. The quality of the included meta-analyses was assessed using AMSTAR questionnaire.

Out of 101 studies, twenty-two studies with twenty-six effect sizes (ES) were eligible for inclusion.

Sixteen ES showed significant improving effect of 
n-3 supplementation on depression symptoms among which eleven ES had small ES. The other studies observed no significant effect.

Available evidence suggests that 
n-3 PUFA (EPA, DHA) supplementation could be considered as an effective add-on therapeutic approach in relieving depression symptoms.

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