Food and Behaviour Research

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Low serum iron in patients with neuroleptic-induced akathisia and dystonia under antipsychotic drug treatment

Horiguchi J. (1991) Acta Psychiatr Scand. 84(3): 301-3. 

Web URL: View this and related abstracts via PubMed here


The concentration of iron was determined in the serum of 35 patients; 10 with akathisia, 8 with dystonia and 17 without akathisia or dystonia.

The patients exhibiting akathisia or dystonia had significantly lower serum concentration of iron than the patients without akathisia or dystonia. Neuroleptic-induced akathisia or dystonia may be facilitated by the low serum iron.


This study's findings add to those from previous research, suggesting that iron depeletion might be one of the factors contributing to akathisia - a syndrome involving extreme motor restlessness and emotional agitation that can be a side-effect of some anti-psychotic medications.