Food and Behaviour Research

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15 July 2014 - MedicalXpress - Defects in fatty acid transport proteins linked to schizophrenia and autism

Defects in Fatty Acid Binding Proteins (FABPs) may help to explain the pathology in some cases of schizophrenia and autism spectrum disorders.

FAB RESEARCH COMMENT:

The underpinning research article can be found here: Schimamoto et al, 2014 - Functional characterization of FABP3, 5 and 7 gene variants identified in schizophrenia and autism spectrum disorder

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Published in the journal Human Molecular Genetics, the study reported that fatty acid binding proteins (FABPs), a component of lipid metabolism, are genetically linked to schizophrenia and autism spectrum disorder (ASD) in humans and dysfunctional behaviors in mice. The findings provide support for the involvement of lipid metabolism in the spectrum of cognitive disorders.

"Identification of FABP mutations in humans may to help us take a personalized treatment approach," said Dr. Yoshikawa. "We hope our finding will lead to the development of tailor-made therapies, providing patients with molecules that complement deficiencies caused by their particular mutation."