Food and Behaviour Research

Donate Log In
Advanced Search

Alcohol: What Women Need to Know - BOOK HERE

Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders.

Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK (2013) Cell 155(7) 1451-63 Elsevier Inc

Web URL: Please find the OPEN ACCESS paper and related research on PubMed here

Abstract:

Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by core behavioral impairments; however, subsets of individuals display a spectrum of gastrointestinal (GI) abnormalities.

We demonstrate GI barrier defects and microbiota alterations in the maternal immune activation (MIA) mouse model that is known to display features of ASD.

Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in communicative, stereotypic, anxiety-like and sensorimotor behaviors.

MIA offspring display an altered serum metabolomic profile, and B. fragilis modulates levels of several metabolites.

Treating naive mice with a metabolite that is increased by MIA and restored by B. fragilis causes certain behavioral abnormalities, suggesting that gut bacterial effects on the host metabolome impact behavior.

Taken together, these findings support a gut-microbiome-brain connection in a mouse model of ASD and identify a potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders.

FAB RESEARCH COMMENT:

Please see also: 

11 March 2015 - MNT - The gut microbiome: how does it affect our health?

Kang et al., 2013 - Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children

Schmidt et al., 2014 - Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers.

 

Food and Behaviour Research is a registered charity (No SC034604) and a company limited by guarantee (Co No SC 253448)

Newsletter Signup

Sign up here to receive our free newletters.

Useful Links

Contact Us

FAB Research 
23 Carlton Road
Oxford
OX2 7SA

Important Notice

Medical opinion and guidance should always be sought for any symptoms that might possibly reflect a known or suspected disease, disorder or medical condition. Information provided on this website (or by FAB Research via any other means) does not in any way constitute advice on the treatment of any medical condition formally diagnosed or otherwise.

Site by Redstone Websites. Easy to Use Web Content Management. 2024 © All Rights Reserved.